Journal:
Article Title: The Effect of the Nonionic Block Copolymer Pluronic P85 on Gene Expression in Mouse Muscle and Antigen Presenting Cells
doi: 10.1016/j.biomaterials.2008.10.064
Figure Lengend Snippet: Effect of P85 on expression of NFκB related genes in C2C12-CMVluc cells. a Total RNA was assayed using Oligo GEArray® Mouse NFκB Signaling Pathway Microarray and gene expression was analyzed by GEArray Expression Analysis Suite software (see http://www.superarray.com/gene_array_product/HTML/OMM-025.html for detailed list of genes and layout). Only genes exhibiting at least 2-fold increase in expression are presented. ( i ) NFκB pathway: ( 3, 4, 30, 72, 77, 78, 70, 84 ) transcription factors; ( 6, 10, 11, 108, 110, 112, 66, 74 ) other factors; ( 53, 54, 56, 60, 61, 64, 87, 88, 71, 80 ) kinases; ( 99, 103 ) ligands and receptors; ( 100, 113 ) inflammatory response, extracellular or membrane molecules. ( ii ) activation of NFκB pathway: ( 8, 105 ) ligands and receptors; ( 35, 5, 22 ) IκB kinase/NFkB cascade; ( 37 ) transcription factor; ( 32 ) extracellular or membrane molecules; ( iii ) NFκB responsive genes: ( 42, 48 ) ligands and receptors, or cytokines.
Article Snippet: Effect of P85 on expression of NFκB related genes in C2C12-CMVluc cells. a Total RNA was assayed using Oligo GEArray® Mouse NFκB Signaling Pathway Microarray and gene expression was analyzed by GEArray Expression Analysis Suite software (see http://www.superarray.com/gene_array_product/HTML/OMM-025.html for detailed list of genes and layout).
Techniques: Expressing, Microarray, Gene Expression, Software, Membrane, Activation Assay